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Parsons DW, Jones S, Zhang X, Lin JC, Leary RJ, Angenendt P, et al

Biochem Pharmacol 159:110

Nrf2, a key endogenous antioxidant transcription factor, is activated by the dissociation of the Keap1 protein, subsequently entering the nucleus to regulate the expression of antioxidant genes in conjunction with ARE elements (Vriend and Reiter, 2015)

Trim21 modulates endoplasmic reticulum-associated degradation and sensitizes cancer cells to ER stress-induced apoptosis by inhibiting VCP/Npl4/UFD1 assembly