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The iron chelator DFO retards photoreceptor degeneration in animal models of RP, supporting a role for ferroptosis in RP progression (244)

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124 DUBs in metabolic disorders DUBs, which reverse ubiquitination and regulate protein stability, localization, and activity, play critical roles in metabolic pathways and demonstrate both detrimental and protective effects in metabolic diseases

These data together with the fact that the antiapoptotic protein Bcl-2 is involved in the formation of pores in the membrane indicate the ability of members of the Bcl-2 protein family to serve as mediators of GSH translocation into the nucleus [26, 30]