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Our model suggests that the large male-female differences in GSH concentration and the velocity of its synthesis cause females to be less sensitive to APAP toxicity compared to males

Fertil Steril 2009;92:61-67 Walter AJ, Hentz JG, Magtibay PM, et al

doi:10.1172/JCI39104

Neurotransmitter Imbalance (The Monoamine Hypothesis) The monoamine hypothesis of depression originated with research in the 1950s that found that an MAO-inhibiting drug had beneficial effects on mood in depressed tuberculosis patients