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Moreover, voltage-dependent anion-selective channel protein 1 (VDAC1)-mediated mitophagy has been also reported [55]

In addition, it has been demonstrated that ROS are also actively involved in the formation of NETs [109], autophagy [110,111,112], chemoattraction and activation of the inflammasome [113,114,115], programmed cell death of infected reservoirs [116, 117], antigen presentation, T-helper cell activation and lymphocyte proliferation [118,119,120,121]

A noteworthy observation was that several men required concurrent use of antiestrogen therapies such as aromatase inhibitors or tamoxifen to address gynecomastia or elevated estradiol levels

Thus, the lack of evidence might have limited the conclusions that could be drawn