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Notably, excessive acylcarnitine accumulation can further suppress Akt phosphorylation and impair glucose uptake, thereby establishing a vicious cycle that progressively exacerbates insulin resistance [121]

227(10):852-9 E Giovannucci - Tomatoes, tomato-based products, lycopene, and cancer: review of the epidemiologic literature - J Natl Cancer Inst - 1999 Feb 17

also conducted a randomized observational double-blind placebo-controlled trial (N = 92 LOE2a) which showed that LC reduced the incidence and severity of degenerative diseases in elderly patients