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Description

Vigorous shaking causes foaming and can lead to peptide aggregation or denaturation

[0373] Although A2-K138F had the highest binding antibody titer and second highest neutralizing antibody titer, this construct was found to form aggregates in solution, indicating potential improper protein folding, and was thus eliminated from further evaluation

Orthopaedic surgery is uniquely sensitive to small shifts in perioperative risk, particularly in implant-based procedures where complications carry disproportionate consequences