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An increasing amount of research associates prediabetes, obesity, and metabolic syndrome with the risk of developing both DPN and chronic sensorimotor peripheral neuropathy (CSPN)

Nevertheless, our findings in erythrocytes and previously published in SCD cardiac tissues 46 support that, in addition to inflammation suppression 23 and fetal globin induction 31,63,64 , DMF displays anti-oxidative and ferroptosis stress effects to alleviate SCD clinical severity, and therefore, might be pursued as a new treatment option