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The degeneration of neurons producing dopamine in the substantia nigra leads to a depletion of dopamine within the striatum, disrupting the finely tuned excitatory and inhibitory signaling in the basal ganglia

Quantification of the synergy using multidimensional synergy of combinations (MuSyC) 37 technique for AXT050 and sorafenib at steady state suggest an inconsequential synergistic efficacy ( obs = 0.001 and 0.035 for pAkt and pERK, respectively), as well as a negligible antagonistic potency (log( 2 ) = 0.02 and 0.05 for pAkt and pERK, respectively)

The first step is detoxification, and IV drug detox can make this process more comfortable and potentially more successful

PCA and PDC are recognized as core phenazines