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Finally, we provide a critical assessment of advances in therapeutics development and drug re-purposing, gaps in knowledge and priorities for medicines development going forward

Her positivity and confidence reassured meshe genuinely believed in the possibility of change and gave me a renewed sense of hope

However, it is disappointing that IGF-1 has not been shown to play a very significant role in promoting tendon healing in clinical trials, which could reflect our poor understanding of the molecular mechanisms by which IGF-1 is involved in promoting tendon regenerative healing

doi: 10.1016/j.cmet.2017.02.005, 20