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The resulting glutamine surplus aggravates glutamine-induced osmotic stress in the cytoplasm, at the same time rendering more glutamine available for (i) its Slc7a6-mediated exchange for extracellular arginine, which increases intra-astrocytic accumulation of reactive nitrogen species (ii) glutamine transport to astrocytic mitochondria, which leads to mitochondrial dysfunction (the Trojan Horse mode of action)

The increased production and degradation of AMP leads to hypoxanthine production (Fig

In the whole study population, the mean serum 25-hydroxyvitamin D level was 25 ng/mL at baselinea level above the threshold for vitamin D deficiency