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Dysfunction in mitochondria can lead to electron leakage in the electron transport chain, resulting in overproduction of ROS such as superoxide anions and hydrogen peroxide ( Endoplasmic reticulum oxidative stress: The endoplasmic reticulum (ER), responsible for protein synthesis and folding, is vulnerable to oxidative stress

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MTHFR mutations are inherited from both parents, meaning you can receive a defective gene from either your mother or father

Zeppenfeld et al., 2014)