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Grazioli and Pugin, 2018)

found that targeting cGAS and inhibiting lactylation modifications can promote the transition of microglia from the M1 phenotype to a repair phenotype [110], the addition of lactate has no effect on the expression of A2 astrocytes and only weakens M1 polarization process [57]

"Short periods" means 2448 hours maximum under controlled low-humidity conditions

Citation79,Citation80 Similarly, Kaposis Sarcoma-Associated Herpesvirus (KSHV) mediates host cell glutaminolysis to promote the proliferation of KSHV-transformed cells, and profile analysis of high-throughput RNA sequencing has revealed that the expression levels of many enzymes (such as GLS2 and GOT2) in the glutamine pathway are upregulated by KSHV infection ( Citation8184 As there is competition for glutamine between immune and host cells, viral infection leads to an upregulation of glutamine catabolism in host cells, resulting in a downregulation of glutamine uptake by immune cells and causing changes in the distribution of CD4 + T cell subtypes