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Since natural glutathione production also decreases, there's little defense against the increase in oxidative stress

Hamming I, Timens W, Bulthuis ML, Lely AT, Navis G, van Goor H

There is no reason to suspect such phenomena are isolated to chronic disease and do not occur alongside or as a consequence of acute inflammatory events such as those which cause critical illness: The acute phase of critical illness is undoubtedly characterized by tremendous immune activation and consequential free radical mediated damage (53, 54)

These authors further speculate that the natural process of brain masculinization puts males at risk of ASD by moving them closer to a vulnerability threshold, breached by refractory inflammation during critical periods of brain development [574]