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It plays a key part in boosting neuronal health and the micronutrients deficiency has been associated with oxidative stress, programmed cell death and necrosis of neurons eventualizing into a plethora of neurodegenerative disorders (Vali et al., 2025)

Aside from the rapid development of the acquired resistance, the limited targeting of specific KRAS mutations poses another significant challenge for drug development, given the diversity of oncogenic KRAS mutations

Crosstalk through PERK Protein kinase-RNA like ER kinase branch can induce NF-B activation essentially by translation attenuation, including the free IB, mediated by phosphorylated eIF2

Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis