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Trends Biochem Sci 44(5):401414 Wen Z, Liu H, Li M, Li B, Gao W, Shao Q et al (2015) Increased metabolites of 5-lipoxygenase from hypoxic ovarian cancer cells promote tumor-associated macrophage infiltration

Black cumin seed oil (2.5 mL, every 12 h) given to patients with NAFLD for 3 months attenuated hepatic steatosis and caused a significant reduction in blood triglycerides, LDL-C, and aminotransferases and increase in HDL-C level without affecting blood urea nitrogen, serum creatinine, blood cell count and body mass index as compared to the placebo group [167]

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In the pathogenesis of glioblastoma (GBM) and stroke, these proteins promote the expression of oncogenic and inflammatory genes