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However, as for other peptide hormones, their clinical application is limited by their short circulatory half-life, a major component of which is cleavage by DPP-IV

Reduced range of motion: Spasms can limit the flexibility and range of motion in the affected area, making it challenging to perform everyday activities

Similarly, the instructions for taking the injection as it relates to consuming it with or without food, is similar

Strength points and limitations Based on our knowledge, this is the most updated meta-analysis on this topic, including all available evidence based on our inclusion criteria of including only controlled studies, either RCTs or controlled observational studies, to reach the highest accessible quality of evidence from the available evidence found in the literature