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Inhibitors of FASN (such as TVB-2640, which has advanced to clinical trials) and acetyl-CoA carboxylase (ACC) inhibitors have shown preclinical efficacy in reducing tumor growth and overcoming resistance to targeted therapies

The oxidative stress gene polymorphisms may affect the disease, independently of the type, although there is a high data variability due to the difference in genotype frequency among ethnicities and the possibility of functional compensation by other genes

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This finding highlighted that Bcl-6 gene was down-regulated whereas PPARG was up-regulated, in turn, might be leading to hepatic fat deposition and hepatocellular apoptosis (311)