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Cisplatin: Mode of cytotoxic action and molecular basis of resistance

Thomas DM

One possible explanation is that the free iron in cells cannot be directly discharged out of cells in the form of ferric iron, but relies on ceruloplasmin and hephaestin to catalyze ferrous iron into ferric iron [59, 60]

Acting as an accelerator, these translocated signals activate hepatic innate immunity (e.g., Kupffer cells via TLR4/NF-B), driving steatosis, inflammation, and fibrosis