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doi: 10.4049/jimmunol.1301859 40 ShiLZWangRHuangGVogelPNealeGGreenDRet al

Meanwhile, these mutated genes can alter the metabolic signaling pathways such as hypoxiainducible factor 1 (HIF1) pathway, regulate glycolysis and mitochondrial function, and thus increase the production of ROS [143]

If you are a habitual heavy drinker, the negative effects of alcohol will eventually cause more severe and permanent liver damage