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the findings, however, were not statistically conclusive for the effects of this clinical trial on the incidence of postpartum depression (Slykerman et al., 2017)

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General MTHFR Symptoms Beyond the systems above, many people with an MTHFR gene mutation report broader symptoms linked to inflammation, detoxification issues, and low B-vitamin activity: Chronic fatigue Eczema, asthma, hives, and allergies Chronic inflammation or pain Low immunity and frequent illness High homocysteine, low B12, or elevated liver enzymes Medications That Can Worsen MTHFR Gene Symptoms Certain drugs deplete folate or B12, reducing your bodys methylation capacity and aggravating MTHFR mutation symptoms

Yin Z, Lee E-S, Ni M, Jiang H, Milatovi D, Lu R, Farina M, Rocha JBTda, Aschner M (2011) Methylmercury-induced alterations in astrocyte functions are attenuated by ebselen