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Striving (Starving to be Fit) Targeting Autophagy in Acute Myeloid Leukemia

CB-1158 could block myeloid cell-mediated inhibition of T cell proliferation, increase the number of tumor-infiltrating CD8 + T cells and NK cells, and increase the expression of inflammatory factors and interferon-, thereby changing the immune microenvironment to promote inflammation and reduce tumor immune escape, inhibiting tumor cell proliferation

These backup mechanisms facilitate the survival and proliferation of cancer cells [26,48,52]

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