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The nutrient deficiency can also activate the NOD-like receptor (NLR) family and pyrin domain-containing 3 (NLRP3) inflammasome and induce IL-1 secretion in high fat diet-induced atherosclerosis animal model 48 , whereas zinc supplementation can inhibit NLRP3 inflammasome activation through its antioxidant effects in an in vitro study 49

PLC 2 Phosphatidylinositol-specific phospholipase C gamma 2 (PLC2) has emerged as a significant regulatory enzyme in cellular signaling, primarily through its catalytic role in breaking down membrane-bound phospholipids to produce diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) [157]

Melanocortin-4 receptor in the medial amygdala regulates emotional stress-induced anxiety-like behaviour, anorexia and corticosterone secretion

10.1016/j.semcancer.2020.05.011 87 VermaS.SinghA.MishraA