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312 Platelets, which are responsible for approximately 90% of circulating A, 313 are overactivated with ageing 314,315 and are reported to release more A and subsequently induce A deposition in the brain and cognitive impairment

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Mitochondrial disease refers to a group of clinically heterogeneous disorders caused by dysfunction in the mitochondrial respiratory chain, often due to mutations in mitochondrial DNA (mtDNA) or nuclear DNA (nDNA) that encodes mitochondrial proteins

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