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What causes this catastrophic failure

[PubMed] [Google Scholar] 173.Peterson CD, et al

It is intended solely for use by qualified professionals in controlled laboratory environments conducting in vitro studies, analytical testing, or preclinical research

In particular, the nucleotide excision repair (NER) system is believed to resolve the majority of DNA lesions provoked by CDDP, 53, 54 although components of the mismatch repair (MMR) machinery have also been implicated in this process (at least in its detection, as opposed to resolution, phase)