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Conditions that predispose to accumulation of excess iron can be hereditary (e.g., hemochromatosis) or acquired (e.g., excess iron ingestion, chronic liver disease)

Among these, inflammatory conditions, such as IBD, and functional bowel disorders, such as IBS, are both characterized by a well-established microbiota dysbiosis associated with impairment of intestinal permeability

doi: 10.1146/annurev-physiol-021014-071931 74 KobayashiKSalathMPrattMMCartagenaNJSoloniFSeyboldZVet al

Chest Pain: Chest pain and breathlessness may occasionally occur with high-speed IV drips, which is why glutathione injections should be given slowly