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Cerebral vasculitis and ischemic optic neuropathy were considered owing to the history of optic neuritis and neurological symptoms

AOD9604 vs Intact hGH in Obesity Models A direct head-to-head comparison of AOD9604 and intact hGH in obese and lean mice confirmed that both compounds significantly reduced body weight gain in obese animals through increased fat oxidation and lipolysis stimulation but that AOD9604 achieved this without the hGH receptor binding, IGF-1 stimulation, hyperglycaemia, or reduced insulin secretion associated with full-length hGH treatment

10.1111/j.1600-065X.1995.tb00680.x 9

The manufacturer submits this data to the FDA, and the FDA reviews and approves it