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Lim ZW, Wang ID, Wang P, et al

Aging is associated with higher expression of metallothionein mRNA, reducing zinc bioavailability, and supplementation can restore zinc levels, enhancing NK cell cytotoxicity [210, 211]

Furthermore, single-cell metabolomics reveals that astrocytes in diabetic stroke models exhibit pathological lipid droplet accumulation, diverting lipid-derived substrates away from neuronal salvage pathways, a metabolic behavior absent in non-diabetic, age-matched controls