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All studies are conducted exclusively within non-clinical, in-vitro research environments designed for scientific investigation

The subsequent release of cytokines, such as interleukin-1 beta (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-), and of reactive oxygen species (ROS) from microglia generates a harmful microenvironment in which reactive astrocytes acquire a neurotoxic A1 phenotype [8, 13,14,15,16,17,18]

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Genetic study of FGF19 receptor variants in gallstone disease