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This document from NHS England put the total number as of 2020, for the UK, at 9.15 million people

Khawaja I, Yingling K, Bukamur H, Abusnina W

Rare but serious problems can happen, and some medicines might not work right with B12 shots

One of the major drawbacks is their large molecular mass of about 150 kDa, responsible for slow kinetics and limited tumor penetration with only approximately 20% of the administered dose reaching the tumor site [85]