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2 Energy metabolism in neurons 2.1 Core characteristics and substrate preference of neuronal metabolism Neurons, in comparison to glial cells, maintain a higher energy level due to their continuous need to generate action potentials, synaptic potentials, and neurotransmitters

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Results GSH depletion induces cell death in RPE cells To evaluate the effect of GSH depletion on the RPE cells, we used three different approaches: depletion of Cys 2 from cell culture media, treatment with buthionine sulphoximine (BSO, 1000 M) to block de novo synthesis of GSH, or treatment with erastin (10 M), an inhibitor of system x c 1

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