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Without carbidopa, so much levodopa would need to be ingested to allow for a small amount to make it into the brain, that the side effects of the levodopa, specifically nausea, would not be tolerated by most people

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In treatment of acute exacerbations of multiple sclerosis daily doses of 200 mg of prednisolone for a week followed by 80 mg every other day or 4 to 8 mg dexamethasone every other day for 1 month have been shown to be effective