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Thus, an age-dependent decrease in GSH levels could contribute to the onset of many age-related diseases, but exactly how normal aging influences the expression of GS and GCL at a molecular level remains unclear [79,83]

Furthermore, these membrane-bound and soluble hydrolases may also act as monophosphatases of the diphosphonucleotides, catalyzing the hydrolysis of ThDP to ThMP (Figure 3)