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The Neh2 domain is a regulatory domain containing the DLG and ETGE binding motifs, through which NRF2 interacts with its major negative regulator, KEAP1, and is essential for the KEAP1-mediated degradation of the protein by the proteasome [128, 143,144,145]

[DOI] [PubMed] [Google Scholar] 33.Ozawa A., Brunori G., Cippitelli A., Toll N., Schoch J., Kieffer B.L., Toll L

As such, the onset of low-grade inflammation is achieved, as evidenced by associated elevated concentrations of circulating cytokines and acute-phase proteins in the bloodstream of both smokers and patients with COPD compared to healthy nonsmokers [17]

A genomic case study of desmoplastic small round cell tumor: comprehensive analysis reveals insights into potential therapeutic targets and development of a monitoring tool for a rare and aggressive disease