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It is possible that thiol compounds reduce Cu 2+ to Cu + directly in the active site of SOD1 53 , thus changing its coordination geometry to non-tetrahedral and facilitating ligand replacement (PAR binding) 52

Okumoto, K

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Similarly, although some data suggest that THRB gene variants may affect thyroid hormone action and contribute to immune dysregulation, these findings have not been consistently replicated, highlighting the need for further well-powered studies in diverse cohorts (Table 2)