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Through activation of the Nrf2antioxidant response element (ARE) signaling axis, GSH upregulates cytoprotective enzymes such as heme oxygenase-1, glutathione peroxidase, and NAD(P)H quinone oxidoreductase-1, thereby enhancing cellular resistance to oxidative injury [10]

Pseudoprogression and pseudoresponse: imaging challenges in the assessment of posttreatment glioma

36 KonK.IkejimaK.OkumuraK.AoyamaT.AraiK.TakeiY.et al (2007)

Among its known binding partners are E3 ligases TRIM27 and RNF41, and the deubiquitinases USP7 and USP8, which it recruits to regulate the ubiquitination and stability of diverse targets (Tacer and Potts, 2017