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Abbreviations AHL : Animal Health Laboratory AIC : Akaike Information Criterion BCS : Body condition score CIDR : Controlled internal drug release CV: Coefficient of variation DHR : Dermal hypersensitivity response ELISA: Enzyme-linked immunoassay GD: Gestation day GPx: Glutathione peroxidase GSH: Glutathione GSSG: Glutathione disulfide ICP-MS: Inductively couples plasma mass spectrometry IFN: Interferon Ig: Immunoglobulin IL: Interleukin IP-10: Interferon gamma-induced protein 10 iSe: Inorganic Se LPS: Lipopolysaccharide LSM: Least squares means NADPH: Nicotinamide adenine dinucleotide phosphate NK: Natural killer oSe: Organic Se OVA: Ovalbumin PBS: Phosphate-buffered saline PPD: Postpartum day S: Sulfur Se: Selenium SeCys: Selenocysteine SeMet: Selenomethionine TMB: 3,3,5,5-Tetramethylbenzidine References Hatfield DL, Berry MJ, Gladyshev VN

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These findings, along with the fact that loss of function mutations in ATP13A2, cause juvenile-onset Parkinsons disease 19 , reinforce the link between polyamine homeostasis and the pathogenesis of this neurodegenerative disorder

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