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Among them, dual agonists of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors, such as tirzepatide, or single GLP-1 analogs (semaglutide) have shown significant efficacy in promoting weight loss and improving glycemic control [9, 92]

[7] There are three major families of superoxide dismutase, depending on the protein fold and the metal cofactor: the Cu/Zn type (which binds both copper and zinc), Fe and Mn types (which bind either iron or manganese), and the Ni type (which binds nickel)

The hydroxyl of Tyr375, O 2 of Glu425 and the NZ of Lys452 are within hydrogen bonding distance of the O4, O3 and O2 atoms of the ribose, respectively (Figure 2)

Zhou et al., 2018)