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In this stage, amyloid plaques infiltrate the midbrain and medulla and NFTs are found in neocortical association cortices (Koychev et al., 2020)

These mediators, including microbial structural components and metabolic byproducts, act as molecular messengers that transduce local microbial activity into systemic physiological or pathological responses (Fig

A key focus is placed on the dysregulation of the kynurenine pathway of tryptophan metabolism, which mechanistically links immune activation to neurotransmitter imbalances