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The diagnosis of BPAN was established by identification of pathogenic variant in WD repeat domain 45 ( WDR45 ) gene encoding for propeller protein

Weve all been there, and we know the struggle is real

Animal and in vitro experiments have further verified its barrier repair effect: Butyrate can promote proliferation and mucin secretion of intestinal epithelial cells (IPECs, Caco-2, HT-29), enhance the expression of tight-junction proteins (ZO-1, Claudin-1, Claudin-2), and maintain colonic mucosal integrity (82)

hORF6 is the founding member of the Prx6 subfamily 25 and carries a single cysteine residue, similar to AnPrx6