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Finally, standardizing VR protocols and validating their efficacy through large-scale clinical trials will be essential for establishing VR as a mainstream approach in cognitive rehabilitation and dementia prevention

We assign each element into one of five classes: (i) essential for all life, (ii) essential for many organisms in all three domains of life, (iii) essential or beneficial for many organisms in at least one domain, (iv) beneficial (and rarely, essential) to at least some species, and (v) of no known beneficial use

The recovery from PSD also correlated with normalization of daytime sleepiness, sleep structure and some neuroendocrine functions including the glycometabolic and stress-related hormones