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Description

The conjunctival goblet cells produce mucins to moisturize and protect the ocular surface, as well as immunomodulatory factors, such as TGF- and retinoic acid, which have been implicated in dampening immune activation of conjunctival antigen-presenting cells (APCs) 2,3

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10.1002/hep.22904 127

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Thus, targeted DTP cells therapy is particularly interesting which only needs to inhibit the essential adaptive pathways to prevent DTP cells formation or restore drug-sensitivity to DTP cells

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Human evidence for TB-500 is limited to a single Phase I safety and pharmacokinetics trial

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