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The reactive species oxidize the different types of amino acids present in the protein and result in the generation of the protein-protein cross linkage which further results in the denaturation, loss of protein functioning, loss of transport protein and receptor functioning, and loss of enzymatic activity

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It was cloned for the first time using the Neh2 domain of NRF2 as bait in a yeast two-hybrid system by Yamamoto and coworkers [118]

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