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As a result, it has a relatively low incidence of producing drowsiness compared to clonidine (Chien et al, 1990

The inhibition of GSH recycling from GSSG does not appear to impact GSH content and cell survival

20 Induction of necroptosis after treatment with APR-246 in our cells was excluded due to the absence of protection by more specific necroptosis inhibitors (Necrostatin 1s and Necrosulfonamide), 21 , 22 and due to the absence of MLKL phosphorylation, a key marker in necroptosis 21 ( Online Supplementary Figure S1A and B )