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Embodiment 168 The formulation according to any one of embodiments said formulation is formulated for administration via a route selected from the group consisting of oral administration, nasal administration, rectal administration, intraperitoneal injection, intravascular injection, subcutaneous injection, transcutaneous administration, and intramuscular injection

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Biological plausibility suggests BDNF receptor desensitization could occur with chronic stimulation a 2025 rodent study found that BDNF-stimulating compounds led to receptor downregulation within 16 weeks, requiring higher doses to maintain effect