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As aforementioned, COX-2-derived PGs disrupt insulin signaling by activating the STAT3/SOCS3 signaling pathway in the liver or interacting with TNF- and ILs in WAT (37,71,78), whereas, in obesity, PGD2 and PGE2 mediate macrophage polarization and infiltration with downregulated TNF-, MCP-1 and IL-6 in WAT, leading to an improvement in peripheral insulin resistance (79,82)

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trispora were measured relative to the transcript levels of the translation elongation factor 1, encoded by the tef1 gene, which is independently transcribed