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It upregulates the expression of vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), and their respective receptors at sites of injury, directly promoting angiogenesis and epithelial repair

Overexpression of Histone H1.3 was shown to suppress the growth of ovarian cancer cells, H1.3 also suppresses the expression of the noncoding gene H19 (Medrzycki, et al 2014)