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Sporadic inclusion-body myositis: conformational multifactorial ageing-related degenerative muscle disease associated with proteasomal and lysosomal inhibition, endoplasmic reticulum stress, and accumulation of amyloid-42 oligomers and phosphorylated tau

3.5 CB-839 induces autophagy in CLL cell lines Because glutamine flux regulates mammalian target of rapamycin complex 1s kinase activity, which is responsible for autophagy, we assessed the effects of glutaminase inhibition on autophagy as an alternative mechanism of CB-839mediated cell death ( Figure 4A )

It has been used to induce pyroptosis or caspase-induced inflammatory programmed cell death [145, 146]

Midwifery Res