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This patient's lack of response is due to substrate depletion, not receptor changes

doi: 10.1038/nrc3677 71 DadrasSSPaulTBertonciniJBrownLFMuzikanskyAJacksonDGet al

The 4 allele has been linked to myelin breakdown and accelerated cognitive decline in AD, and myelin abnormalities are also reported in schizophrenia

Additional studies indicate antifibrotic and vasodilatory activity relevant to cardiovascular and pulmonary disease models, as well as potential relevance in transplantation tolerance research and lacrimal secretion regulation in dry eye-related conditions.