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Additionally, it is important to note that attempts to reverse mitochondrial damage using antioxidant treatment, which specifically targets ROS, have proven to be ineffective ( 8.1 Pharmacological interventions targeting mitochondria Mitochondrial dysfunction plays a significant role in various inflammatory lung diseases, including asthma, COPD, and pulmonary fibrosis

We suggest that this highlights the importance of proactive integrated physical and mental healthcare for all those suffering with HG, regardless of physiological severity

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Specifically, M1 macrophages predominantly utilize glycolysis to sustain their pro-inflammatory functions, whereas M2 macrophages depend on fatty acid oxidation (FAO) and oxidative phosphorylation (OXPHOS) [14]