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202 Similarly, lactate-derived histone Kla, particularly H3K18la and H3K9la, serves as a transcription initiator of key genes to manipulate the metabolic profiles and function of CD8 + T cells, which are vital for antitumor immunity

Similar observations have been reported in animal models, including mice

Owing to its widespread presence in dietary and industrial settings, it poses significant public health risks

[47]: Their study found that when intervening in post-SCI skeletal muscle atrophy by means of a PGC-1 activator, a significant difference in the level of PGC-1 expression appeared in skeletal muscle undergoing the intervention in the early stages of the injury, with no significant difference at the chronic stage